DIRECTIONS
 

• Administer once every week on the same day, regardless of the time or whether it’s taken with food.                 

• Do not exceed the recommended maximum dose of 10mg per week.

• The scheduled day for weekly dosing may be changed if needed, provided there is a minimum of 48 hours (2 days) between doses.

• If a dose is missed, it should be taken as soon as possible within 5 days. If more than 5 days have passed, skip the missed dose and continue with the next dose on the usual weekly day.  

• Protect from direct sunlight and store in refrigeration.

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BENEFITS
 

Metabolic & Weight Loss Benefits

• Rapid fat loss: Clinical trials show 20–24% total body weight reduction over ~48–72 weeks — superior to semaglutide (Ozempic/Wegovy) and tirzepatide (Mounjaro/Zepbound).

• Targets visceral fat: More pronounced reduction in abdominal and liver fat.

• Boosts metabolic rate: The glucagon receptor activity helps maintain resting energy expenditure, preventing the “metabolic slowdown”  seen with other GIP-1 drugs.

• Improved insulin sensitivity: Enhances glucose uptake and reduces insulin resistance.

• Reduces appetite and cravings: Strong appetite suppression due to 

  GLP-1/GIP signalling in the brain’s satiety centres.

 

Cardiovascular & Metabolic Health

• Lowers blood sugar and HbA1c: Strong anti-diabetic effects comparable to semaglutide or tirzepatide.

• Reduces triglycerides and LDL cholesterol: Improves lipid profile significantly.

• Lowers blood pressure: Both through weight loss and improved vascular tone.

• Reduces inflammation markers (CRP, IL-6): Helps protect against metabolic syndrome.

 

Body Composition & Muscle Preservation

• Less lean mass loss: Unlike some GLP-1 agonists, Retatrutide helps 

  preserve muscle tissue thanks to glucagon’s mild anabolic effect.

• Better body recomposition: Users report a leaner, more defined look  due to greater fat-to-muscle ratio improvement.

• Synergy with resistance training or HGH: When combined with exercise or peptides like HGH or IGF-1 analogs, fat loss accelerates while muscle retention improves.

 

Cognitive & Energy Effects

• Stabilizes mood and reduces “food noise”: Calmer mental relationship with food.

• Improved mental clarity: Users often report sharper focus due to stabilized glucose.

• More stable energy levels: No sugar highs or crashes.

 

Mechanistic Summary

• GLP-1 receptor agonism: Suppresses appetite, delays gastric emptying, enhances insulin.

• GIP receptor agonism: Enhances insulin secretion and supports fat metabolism.

• Glucagon receptor agonism: Boosts fat oxidation and energy expenditure.

 

Other Emerging Benefits

• May reduce fatty liver (NAFLD/NASH) by improving hepatic fat metabolism.

• Possible anti-aging effects through improved mitochondrial efficiency and lower inflammation.

• Early data suggests improved fertility and hormone balance in obese individuals due to normalized metabolic signalling.